tag:blogger.com,1999:blog-6235733697979948062.post1118042570796969856..comments2024-03-19T00:33:30.191-07:00Comments on our brain tumor cocktails and stories: Micronutrient mix ?Stephen Whttp://www.blogger.com/profile/00777652648990108253noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-6235733697979948062.post-91978068061014599852015-11-09T18:17:35.623-08:002015-11-09T18:17:35.623-08:00The first thing you have to ask about any in vitro...The first thing you have to ask about any in vitro study is this: are the tested concentrations of the drug/compound realistic? Are equal concentrations of free, unmetabolized drug anywhere close to achievable in plasma or target tissue? In vitro evidence should be regarded as the very first indication that a drug/compound is worthy of further study, but by itself it doesn't say very much. <br /><br />In the second study, large anti-invasive effects were seen at a Nutrient Mixture concentration of 500 ug/mL. By weight, the nutrient mixture is about one-quarter green tea extract, of which 35% is EGCG. So, is 44 ug/mL of EGCG achievable? <br />44 ug/mL = 44000 ug/L. Max plasma concentration of unconjugated EGCG after an 800 mg dose is about 440 ug/L, or about 100 times less.<br /><br />The Nutrient Mixture also caused increased glioma cell proliferation by 40% at 50 ug/mL, and by about 10% at 10 ug/mL, and these lower concentrations are probably closer to physiological levels than the higher concentrations. Personally I would not want to dose up on Nutrient Mixture looking at Figure 1, unless there were some in vivo evidence showing actual tumor inhibition in a living body.<br /><br /><br /><br /> Stephen Whttps://www.blogger.com/profile/00777652648990108253noreply@blogger.comtag:blogger.com,1999:blog-6235733697979948062.post-58231750534761269872015-11-09T15:12:32.862-08:002015-11-09T15:12:32.862-08:00Stephen what do you think about the study above?Stephen what do you think about the study above?lucyhttps://www.blogger.com/profile/02577165011534061460noreply@blogger.com