tag:blogger.com,1999:blog-6235733697979948062.post2111582627795775566..comments2024-03-19T00:33:30.191-07:00Comments on our brain tumor cocktails and stories: Drugs to Combine with CCNUStephen Whttp://www.blogger.com/profile/00777652648990108253noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-6235733697979948062.post-50698959334204051682019-02-05T17:46:42.734-08:002019-02-05T17:46:42.734-08:00Stephen--
Many thanks for your thoughtful reply. Y...Stephen--<br />Many thanks for your thoughtful reply. Your understanding of the literature is invaluable and your generosity in sharing your knowledge is boundless. I have just emailed his NO.<br />SJ67https://www.blogger.com/profile/14308699381924208599noreply@blogger.comtag:blogger.com,1999:blog-6235733697979948062.post-70857565701550810952019-02-05T11:44:46.125-08:002019-02-05T11:44:46.125-08:00The data for nimodipine is in vitro, the least rel...The data for nimodipine is in vitro, the least reliable level of evidence. <br /><br />For verapamil, there is rodent evidence for better tumor control when combined with BCNU (a close chemical relative of CCNU), in a subcutaneous glioma model. Although this wasn't an orthotopic model (the brain tumor cells were transplanted into the flank, not into the brain), it still trumps in vitro evidence because it shows that verapamil at physiologically achievable levels can have this chemosensitizing effect in combination with BCNU. <br /><br />http://sci-hub.tw/https://doi.org/10.3171/jns.1990.73.2.0248<br /><br />In contrast, many in vitro studies use drug concentrations that aren't physiologically achievable.<br /><br />There is also some human evidence to support verapamil in other types of cancer. <br /><br />https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968472/<br /><br />I'm sure his doctor would want to check his baseline blood pressure before starting him on a drug such as verapamil, but given the experimental evidence and the limited clinical evidence, I would certainly experiment with the verapamil + CCNU combo. Ben was doing 7 days of verapamil surrounding his CCNU or BCNU days (3 days before, the day of, and 3 days after).Stephen Whttps://www.blogger.com/profile/00777652648990108253noreply@blogger.comtag:blogger.com,1999:blog-6235733697979948062.post-37414929518357127662019-02-04T13:00:46.688-08:002019-02-04T13:00:46.688-08:00Always watch for serious side effects. Oncare had...Always watch for serious side effects. Oncare had told us not to do verapamil because of this. Check with doctors before you take anything. Anonymoushttps://www.blogger.com/profile/01481778798265729567noreply@blogger.comtag:blogger.com,1999:blog-6235733697979948062.post-21770067879477937622019-02-04T12:59:41.092-08:002019-02-04T12:59:41.092-08:00Two years ago my brother was diagnosed with GBM an...Two years ago my brother was diagnosed with GBM and was only given a few months to live. He has had 3 surgeries and lost some of his eyesight on the left side but overall doing well. We have researched many sources including conventional and non-conventional and have found a combo of both works. I would contact Oncare (careoncology.com) immediately. They offer off-label drugs that has helped. I would also recommend u keep a close watch on his blood test results. Using papaya leaf extract has helped keep blood palettes normal. Astragalus has helped with lymophocytes count. Anonymoushttps://www.blogger.com/profile/01481778798265729567noreply@blogger.com