tag:blogger.com,1999:blog-6235733697979948062.post6040100090190617001..comments2024-03-19T00:33:30.191-07:00Comments on our brain tumor cocktails and stories: Metformin and autophagyStephen Whttp://www.blogger.com/profile/00777652648990108253noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-6235733697979948062.post-88395967661282147402015-11-22T15:39:45.331-08:002015-11-22T15:39:45.331-08:00As you know, autophagy is complex, as it can eithe...As you know, autophagy is complex, as it can either be a survival mechanism, or alternatively, lead to autophagic cell death. In an esophageal cancer model co-administration of metformin (intraperitoneally injected) with chloroquine was synergistic and inhibited tumor volume far more effectively than metformin alone. <br /><br />http://www.nature.com/cddis/journal/v5/n2/full/cddis201459a.html#Results<br /><br />http://www.nature.com/cddis/journal/v5/n2/extref/cddis201459x5.jpg<br /><br />However, these ip injections of high dose metformin lead to plasma levels far higher than humans get with typical diabetic doses. I have a hard time believing metformin has much direct effect on glioma cells in the brain, and I focus more on the potential systemic effects (on circulating glucose, insulin, IGF-1, and immune effects).Stephen Whttps://www.blogger.com/profile/00777652648990108253noreply@blogger.com