tag:blogger.com,1999:blog-6235733697979948062.post6666364182105989111..comments2024-03-19T00:33:30.191-07:00Comments on our brain tumor cocktails and stories: Switching Tamox for LetrozoleStephen Whttp://www.blogger.com/profile/00777652648990108253noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-6235733697979948062.post-4453219644925926282015-12-29T05:29:14.742-08:002015-12-29T05:29:14.742-08:00Yes, you are right. The idea was switch in order t...Yes, you are right. The idea was switch in order to avoid blood clots. Thanks for point out the study!Anonymoushttps://www.blogger.com/profile/16909509047473224747noreply@blogger.comtag:blogger.com,1999:blog-6235733697979948062.post-47834013018811632015-12-28T19:35:51.262-08:002015-12-28T19:35:51.262-08:00The work on letrozole and glioma has only been in ...The work on letrozole and glioma has only been in mice so far - no clinical trials, so there is no recommended dose at this time. Also, though GBMs mostly had high aromatase expression in one study, it's not certain to be the case for IDH1-mutant gliomas.<br /><br />Tamoxifen and letrozole are not equivalent, since tamoxifen has multiple possible mechanisms of action besides blocking estrogen receptors. Is your reasoning for switching away from tamoxifen that blood clotting could be a problem with high dose tamoxifen now that she is a bit incapacitated? If so, that might not be a problem given the recent evidence that patients with IDH-mutant gliomas do not suffer nearly as frequently from thrombotic events (blood clotting).<br /><br />https://soc-neuro-onc.conference-services.net/reports/template/onetextabstract.xml?xsl=template/onetextabstract.xsl&conferenceID=4558&abstractID=916404<br /><br />Mutant IDH1/2 suppresses local and systemic thrombosis in glioma patientsStephen Whttps://www.blogger.com/profile/00777652648990108253noreply@blogger.com