tag:blogger.com,1999:blog-6235733697979948062.post8929328361908002061..comments2024-03-19T00:33:30.191-07:00Comments on our brain tumor cocktails and stories: Stephen Whttp://www.blogger.com/profile/00777652648990108253noreply@blogger.comBlogger7125tag:blogger.com,1999:blog-6235733697979948062.post-91689056814793904292016-01-03T15:42:03.700-08:002016-01-03T15:42:03.700-08:00How about other agents which are not mentioned in ...How about other agents which are not mentioned in the above list which was approved by Von Gool? How about DCA, Disulfiram, Astragalus, Selenium, Coffeine, Cimetidine, Astragalus, Ashwaganda, Hepasunate, Hepatomether and Artemisinin, Folate, Q10, R-lipoic acid. Any ideas on whih of those to take during immunotherapy?lucyhttps://www.blogger.com/profile/02577165011534061460noreply@blogger.comtag:blogger.com,1999:blog-6235733697979948062.post-40042567877856942442016-01-03T12:13:16.873-08:002016-01-03T12:13:16.873-08:00Given that sildenafil inhibits immune suppressor c...Given that sildenafil inhibits immune suppressor cells (in mice at least), I would consider it a good addition to immunotherapy.Stephen Whttps://www.blogger.com/profile/00777652648990108253noreply@blogger.comtag:blogger.com,1999:blog-6235733697979948062.post-18600392132762195372016-01-03T01:10:52.295-08:002016-01-03T01:10:52.295-08:00I am wondering about Sildenafil if it should be ta...I am wondering about Sildenafil if it should be taken during the the immunotherapy(without the Newcastle virus). Bellow is some article where it states that it should be synergistic. Any opinions? <br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782527/lucyhttps://www.blogger.com/profile/02577165011534061460noreply@blogger.comtag:blogger.com,1999:blog-6235733697979948062.post-8750662627467368092015-12-22T01:52:30.695-08:002015-12-22T01:52:30.695-08:00Hi all,
My friend is being treated at IOZK with V...Hi all,<br /><br />My friend is being treated at IOZK with Van Gool and we went through the list with both him (Van Gool) and Dr. Stucker (at IOZK). Here is what we got with regards to what should & should not be continued while on DC Vaccine therapy:<br /><br />Metformin - Yes<br />Zinc - No<br />Genistein - Yes<br />Silibinin - Yes<br />Green Tea Extract - Yes<br />Curcumin - Yes<br />Resveratrol - Yes<br />Lycopene - Yes<br />Melatonin - Yes<br />Vitamin D - Yes<br />Fish Oil - Yes<br />Boswellia Serrata - Yes<br />Celebrex - Yes<br />Chloroquine Phosphate - No<br />Maitake D Fraction (PSK) - Yes<br />Cannabis Oil - Yes<br />Minocycline - Yes<br />Valproic Acid - Yes<br />Temozolomide - Questionable. Likely no. If yes, STUPP protocol. <br /><br />Hope this helps. Anonymoushttps://www.blogger.com/profile/15213196656063189676noreply@blogger.comtag:blogger.com,1999:blog-6235733697979948062.post-63285629888351359932015-12-16T18:36:47.083-08:002015-12-16T18:36:47.083-08:00Hi Stephen, Van Gool answers selectively so what i...Hi Stephen, Van Gool answers selectively so what i got from him was a "seems fine" in relation to the cocktail i'm on. <br />Cheers,<br />MarkAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-6235733697979948062.post-39567621178124835212015-12-09T14:16:56.703-08:002015-12-09T14:16:56.703-08:00thanks Stephen, i messaged Van Gool so we will see...thanks Stephen, i messaged Van Gool so we will see what he thinks.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-6235733697979948062.post-49679418952705492982015-12-08T14:33:02.565-08:002015-12-08T14:33:02.565-08:00Stefan van Gool and others published a mouse study...Stefan van Gool and others published a mouse study, showing the importance of the immune system in mediating the therapeutic effect of NDV treatment. I'll upload this study to the Immunotherapy folder of the Library.<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/25208916<br /><br />I suggest asking van Gool himself about which supplements would be most helpful and at which time points in relation to NDV administration. There was a recent study showing that suppressing the innate immune response (Natural Killer cells and macrophages) increased the efficacy of virotherapy in a GBM mouse model.<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/26631269<br /><br />Is it possible to supress the innate immune response while activating the adaptive immune response? Is this the best strategy?<br /><br />I would also be concerned about the immunosuppressive effects of the cannabinoids during the vaccine therapy. SSRI antidepressants like fluoxetine may also have immunosuppressive effects, though I haven't seen that being confirmed in cancer models. In fact I've seen cancer studies showing improved immune responses with fluoxetine, so there's definitely mixed evidence.<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/23640520<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/21497159<br /><br />Would be good to discuss these questions with van Gool or another cancer immunologist.<br /><br />Stephen Whttps://www.blogger.com/profile/00777652648990108253noreply@blogger.com