tag:blogger.com,1999:blog-6235733697979948062.post9109761808408374127..comments2024-03-19T00:33:30.191-07:00Comments on our brain tumor cocktails and stories: 39 y/o female - Biopsy resultsStephen Whttp://www.blogger.com/profile/00777652648990108253noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-6235733697979948062.post-38779021288766172016-10-18T12:58:22.132-07:002016-10-18T12:58:22.132-07:00Most of these tests simply rule out that it isn...Most of these tests simply rule out that it isn't an IDH1-mutant lower grade glioma, but they don't provide much insight beyond that.<br /><br />ATRX loss is mostly seen in IDH1 mutant astrocytomas or some types of pediatric gliomas, and was not seen here, as we'd expect.<br /><br />The low expression of p53 means there's not likely a TP53 mutation. <br /><br />1p/19q retained simply means there's no 1p/19q codeletion. That is an alteration almost exclusively seen in IDH-mutant oligodendrogliomas.<br /><br />A more important test for GBM would be EGFR amplification and EGFRvIII mutation, which aren't among the results listed. These tests would be more informative for designing a cocktail, for example chloroquine is likely more effective in EGFR amplified and EGFRvIII positive tumors.Stephen Whttps://www.blogger.com/profile/00777652648990108253noreply@blogger.com