tag:blogger.com,1999:blog-6235733697979948062.post7070510451186439664..comments2024-03-19T00:33:30.191-07:00Comments on our brain tumor cocktails and stories: Questions on my mom's drug cocktail(GBM Patient)Stephen Whttp://www.blogger.com/profile/00777652648990108253noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-6235733697979948062.post-40905587363512392822020-07-28T21:57:30.195-07:002020-07-28T21:57:30.195-07:00I forgot to add the sci-hub link to the Valgancicl...I forgot to add the sci-hub link to the Valganciclovir study:<br />https://sci-hub.tw/https://clincancerres.aacrjournals.org/content/early/2020/05/16/1078-0432.CCR-20-0369.full-text.pdfStephen Whttps://www.blogger.com/profile/00777652648990108253noreply@blogger.comtag:blogger.com,1999:blog-6235733697979948062.post-19025788301353566692020-07-28T21:56:34.284-07:002020-07-28T21:56:34.284-07:00Hi Sahil, I'm glad to hear your mom's scan...Hi Sahil, I'm glad to hear your mom's scan is showing no progression at the nearly three year mark!<br /><br />I'm not a doctor and have no personal experience with valganciclovir, but a recently published retrospective study of using this drug for GBM patients stated <br />"Valganciclovir was given at the standard recommended dose: 900 mg twice daily for 3 weeks followed by 900 mg daily until disease progression (n=12 cases) or palliative status. Severe signs of intolerance were not observed."<br /><br />On the Toxicities page on this blog, I've quoted a study that concluded “The risk of developing toxic retinal chloroquine damage seems to be small or absent even in long term treatment, providing the dose is kept low, not higher than 0.25 g [250 mg chloroquine phosphate] daily for 10 months annually, and the patient is under 50 years old and does not suffer from any other illness which might affect the retina. The total annual dose is thus 70-75 g. Regular ophthalmological checks should then not be essential. In elderly patients, over 50-60, in whom there is the problem of differentiating senile maculopathy from chloroquine-induced maculopathy, regular ophthalmological check-ups are advised.”<br /><br />If I recall correctly, in the Mexican trials of chloroquine for newly diagnosed glioblastoma, the chloroquine was administered daily for 12 months.<br /><br />Can you ask her doctor for further advice, perhaps the doctor who wrote the prescriptions for these drugs?<br /><br /><br />Stephen Whttps://www.blogger.com/profile/00777652648990108253noreply@blogger.com