Inhibition of 13-cis retinoic acid-induced gene expression of reactive-resistance genes by thalidomide in glioblastoma tumours in vivo
In this study, nude mice bearing subcutaneous U251 GBM xenografts were treated orally with either 13-cis retinoic acid (Accutane), or thalidomide, or both. While neither of the drugs alone influenced tumor growth rates, the combination of both drugs significantly slowed tumor growth up to day 18.
I'm not adding this to the library as it is available as a free download from Oncotarget (click on link above).
I just added a short summary of this study to the Repurposed Drugs page on Astrocytoma Options, about halfway down the page in the Rodent Evidence section.
ReplyDeletehttp://astrocytomaoptions.com/repurposed-drugs/