So my brothers tumor has high PKB/AKT . As far as I understood Ben states in his pdf that lovastatin can suppress the PKB/AKT. I noticed that somebody in this group is using statin but not with the temozolomide but with another chemo agent. What do you think about adding it to the mix? My brother does have a high cholesterol.
Statins may have good activity in vitro, and also show anti-glioma activity in flank-injected GBM rodent models. I have yet to see even an animal study showing that statins can cross the blood-brain barrier sufficiently to be therapeutic for brain tumors. This is after all one of the biggest challenges in brain tumor therapy.
ReplyDeleteHere is some article about it but I did not have a chance yet to compare the numbers if it is sufficient crossing or not.
ReplyDeletehttp://www.ncbi.nlm.nih.gov/pubmed/7679171
Here is some article about drug that opens the BBB. I'm not sure if it would be any use for us.
ReplyDeletehttp://www.news.cornell.edu/stories/2011/09/finding-may-permit-drug-delivery-brain
http://www.nature.com/bjc/journal/v108/n3/full/bjc2012536a.html
ReplyDeletehttp://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-12-13 hi! Im new in this war. My mather have gliosarcoma. Im looking for statin pitavastatin its very interested. Its synergic wiht irinotecan.....what do you think about? (sorry for my english).
ReplyDeleteVery thanks