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Wednesday, 23 December 2015

Auranofin

I've just added auranofin to my top 10 GBM drug list.  It is a thioredoxin reductase inhibitor (an enzyme which is strongly overexpressed in GBM), and a broad inhibitor of the PI3K/Akt/mTOR pathway in lung cancer cells, and an inhibitor of phosphofructokinase, one of the most important enzymes in the glycolytic pathway.  It has shown synergy with disulfiram in a recent hepatocellular cancer mouse model.

Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo.


It is included in the CUSP9 protocol at the dose of 3 mg twice daily (starting dose 3 mg once daily).

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9 comments:

  1. Kamkar25 December 2015 at 02:58

    Any one know where to obtain auranofin ?

    Prescription ? Thank you. Happy holidays!

    ReplyDelete
    Replies
    1. Unknown25 December 2015 at 19:27

      A prescription is required and the drug is used against rheumatoid arthritis. mY opinion is fairly low side effects.

      https://www.nlm.nih.gov/medlineplus/druginfo/meds/a685038.html

      CUSP9*
      http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=2408&path%5B%5D=4187

      Delete
  2. AGM25 December 2015 at 08:55

    Is there any known impact/concern with the other meds suggested or with liver toxicity?

    ReplyDelete
  3. Unknown25 December 2015 at 16:20

    Thanks Stephen! Since we are, which would be your top 10 drug list?

    ReplyDelete
    Replies
    1. Unknown28 December 2015 at 09:24

      I just found the list in the library. Thanks!

      Delete
    2. Unknown4 October 2016 at 10:13

      I'm probably being blind, but what file did you find the list under? Thanks!

      Delete
    3. Stephen W4 October 2016 at 13:44

      My top 10 lists were replaced with a file in folder 0 called "pharma and non-pharma list", which a spreadsheet containing relevant data on many of the "cocktail" ingredients we discuss here.

      Delete
  4. Unknown25 December 2015 at 19:20

    Thanks For highlighting Auranofin Stephen!

    ReplyDelete
  5. AGM29 December 2015 at 08:09

    I went to Mexico yesterday to purchase some meds for my husband, I asked about Auranofin and unfortunately the pharmacist hadn't heard of it. If anyone has a suggestion on how to obtain auranofin, please post.

    ReplyDelete