Very interesting and I agree is a potentially productive treatment against GBM.
http://www.cityofhope.org/brain-cancer-2016-using-car-t-cell-therapy-to-fight-tumors
http://www.cityofhope.org/brain-cancer-2016-using-car-t-cell-therapy-to-fight-tumors
I am wondering if it would work for for NON EGFR3 mutant tumors or not
ReplyDeletehttp://www.crownbio.com/car-t-immunotherapy-revs-glioblastoma/
https://www.sciencedaily.com/releases/2017/08/170828140742.htm
ReplyDeleteInteresting article on CAR-T, although not for gliomas.
"Treatment with an investigational CAR T-cell therapy induced complete remission of a brain metastasis of the difficult-to-treat tumor diffuse large-B-cell lymphoma (DLBCL), which had become resistant to chemotherapy -- the first report of a response to CAR T-cells in a central nervous system lymphoma."
Yes that CD19 directed CAR T-cell therapy seems to work very nicely for B-cell lymphomas, and from what I've heard it will probably be approved this year.
Deletehttp://www.iflscience.com/health-and-medicine/revolutionary-geneediting-cancer-treatment-gets-green-light-in-the-us-for-the-first-time/
DeleteIt just got FDA approved (-first FDA approved CAR-T therapy)! I posted that link few days ago because it seems CAR-T can also work on solid tumors in central nervous system. In that study T-cells targeted "CD19 protein expressed on most B-cell leukemias and lymphomas". So in theory if one changed that targeting to glioma expressing proteins it should work on us too? Easier said than done though :)
New information on City of Hope's IL13RA2 directed CAR T-cell therapy, currently in clinical trial.
ReplyDeletehttps://www.ncbi.nlm.nih.gov/pubmed/29769444