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Monday, 5 December 2016

Triple combination of dual checkpoint blockade + radiosurgery -> 100% mouse survival

http://clincancerres.aacrjournals.org/content/early/2016/12/04/1078-0432.CCR-15-1535.long

I don't recall seeing a mouse study this successful before.  This study utilized the orthotopic, syngeneic GL-261 mouse glioma model.  Triple combination of PD-1 antibody, TIM-3 antibody, and stereotactic radiosurgery led to 100% mouse survival at day 100, while all untreated control mice were dead by day 30.  Furthermore, the "cured" mice were completely resistant to new tumor formation when re-challenged with glioma cells.  I'll upload this study to the Library, in the Immunology and Immunotherapy folder, Checkpoint inhibitor subfolder.




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3 comments:

  1. Pu5 December 2016 at 19:46

    The results sound inspiring! Looking forward to see similar studies not only on mices.

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  2. Matjaz6 December 2016 at 01:41

    Interesting! It is the first time I'm hearing about TIM-3, but quick google search gives few interesting and inspiring journals from past few years. Maybe it will be a next big thing in immunotherapy research.

    Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints:
    http://www.nature.com/articles/ncomms10501

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  3. Unknown7 December 2016 at 14:14

    Very interesting!

    ReplyDelete