have anyone tried the liquid version of Maitake-D? my wife is hard to swallow too many tablets and capsules, so i am trying to get liquid versions for her. the quesiton is about the dosage, similar to tablet issue, it says: standardized to contain 30% D-fraction 22mg, that is for each 6 drops, if it means each 6 drops contain 22mg D-fraction, 100mg per day means around 27 drops a day. if 22mg only contain 30% D fraction, 100mg per day means around 90 drops a day. which one is correct?
Roy
Given how loosely regulated supplements are, I personally wouldn't be satisfied unless I took a sensitive postal scale and determined how many drops were needed to make up one gram--not all drops are the same size, depending on the dropper. That gram should contain 300 mg of D-fraction.
ReplyDeleteThat would be true if the product contained 30% D-fraction. However the liquid form of the product contains about 6 grams of PD-fraction per 60 mL bottle (22 mg of PD-fraction per serving x 273 servings). Assuming a density close to 1 gram per mL, PD-fraction makes up about 10% of the product by weight. But the D-fraction is only 30% of the PD-fraction, so D-fraction would only be 3% of the total product by weight.
Delete
ReplyDeleteShort answer: 91 drops per day gives you 100 mg D-fraction and 333 mg of PD-fraction.
Long answer:
The confusing phrasing of the ingredients on the Maitake Wisdom Maitake D fraction product has been an issue for years that keeps coming up. See my comment on this previous post:
http://btcocktails.blogspot.com/2015/08/maitake-d-fraction-sources.html
For the liquid version, as you say, the label says this:
"Maitake PD-Fraction® Standardized to contain 30% proteoglucan; D-fraction 22 mg†"
For the capsule version, the old label used to similarly say this:
"Ingredients
Maitake Mushroom Powder 600 mg†
Maitake PD-Fraction® Standardized to contain 30% proteoglucan; D-fraction 240 mg†
Vitamin C 120 mg (200% of daily value)"
The new label for the capsules doesn't even tell us that PD fraction is standardized to 30% active proteoglucan (D fraction).
This phrasing couldn't be more confusing. It makes it sound as if there's 240 mg of D-fraction in one serving (6 capsules), when in reality (as confirmed by the company in their email) the 240 mg refers to PD fraction, which is 30% D-fraction. Therefore there is 72 mg of D-fraction per 6 capsule serving (72 is 30% of 240).
Likewise, I interpret the label for the liquid form as saying there is 22 mg of PD-fraction per 6 drop serving. This PD-fraction is only 30% proteoglucan (D-fraction), so doing the math tells us there is 6.6 mg of D-fraction per 6 drop serving, or 1.1 mg of D-fraction per drop. Or 100 mg of D-fraction in 91 drops.
At 6 drops per serving and 273 servings per container, there's 1638 drops per container. At 91 drops per day the container would last only 18 days. That would get quite expensive after awhile.
The 100 mg D-fraction cancer dose isn't set in stone. In one of the early publications (1996) by Hiroaki Nanba, cancer patients were treated with 35, 55, 50, 70, 100 and 100 mg of D-fraction daily (number corresponding to individual patients). Unless a person can spare $150 USD every month for 100 mg D-fraction daily, it could be reasonable to reduce the dose to 30-50 mg D-fraction daily, or alternatively to take a full dose every 2 or 3 days or so, with the reasoning that the immune effects of a full dose could last for several days.
In line with Steve's comment, all the calculations are only approximate. I can guarantee that two people measuring out 90 drops will get a slightly different weight at the end, and that if someone were patient enough to measure the number of drops in a container they wouldn't get 1638 drops :)
DeleteMy husband took this for a little while as he had a hard time with all the pills, too. He detested the liquid mushrooms and eventually went back to pill form. The taste was hard for him to take so he mixed it with a shot of smoothie to get it down. I made the mistake of trying to mix his mushroom powder from the capsules into a smoothie, too. He hated that even worse. Good luck to your wife.
ReplyDeleteThank you all for the reply. Sorry for late response something wrong with my connection. Just got the feedback from the company. Stephen is correct, need 91 drops for 100mg.
ReplyDeleteJust check, in the earlier test mentioned by stephen, did different dosage lead to different result?
Roy
This study I mentioned was more of a case series with all different cancer types rather than a formal phase 1 dose finding trial. There is really no way to compare outcomes of the different doses on the basis of this study. If you'd like to check out the study yourself, here is the link:
Deletehttp://www.orthomolecular.org/library/jom/1997/pdf/1997-v12n01-p043.pdf