The most exciting immunotherapy trial recruiting in Canada (in my opinion) is DNX-2401 (adenovirus) + pembrolizumab for recurrent GBM, recruiting in Toronto.
https://clinicaltrials.gov/ct2/show/NCT02798406
The phase 3 (randomized, placebo-controlled) ICT-107 trial is recruiting in Ontario and Quebec, but it's for newly diagnosed GBM, and I would guess that leukapheresis to obtain dendritic cells would have to be done prior to radiation. It's also a long way to travel with a chance of getting placebo. https://www.clinicaltrials.gov/ct2/show/NCT02546102
Finally there are 3 checkpoint inhibitor trials recruiting for *newly diagnosed* GBM. Two are recruiting in Vancouver, one is testing nivolumab versus TMZ for GBM with unmethylated MGMT. https://clinicaltrials.gov/ct2/show/NCT02617589
The other is testing standard of care plus either nivolumab or placebo. https://clinicaltrials.gov/ct2/show/NCT02667587
The third checkpoint inhibitor trial is recruiting in Quebec for newly diagnosed GBM, testing avelumab (a PD-L1 antibody). https://clinicaltrials.gov/ct2/show/NCT03047473
These are the only immunotherapy trials currently recruiting in Canada that I'm aware of, and only one of them is for recurrent GBM.
I investigated the very same question last year when my cousin was being tested for GBM. There was only one neuro-oncologist in Vancouver and so there just isn't the research capacity there that is available in Toronto.
The most exciting immunotherapy trial recruiting in Canada (in my opinion) is DNX-2401 (adenovirus) + pembrolizumab for recurrent GBM, recruiting in Toronto.
ReplyDeletehttps://clinicaltrials.gov/ct2/show/NCT02798406
The phase 3 (randomized, placebo-controlled) ICT-107 trial is recruiting in Ontario and Quebec, but it's for newly diagnosed GBM, and I would guess that leukapheresis to obtain dendritic cells would have to be done prior to radiation. It's also a long way to travel with a chance of getting placebo.
https://www.clinicaltrials.gov/ct2/show/NCT02546102
Finally there are 3 checkpoint inhibitor trials recruiting for *newly diagnosed* GBM. Two are recruiting in Vancouver, one is testing nivolumab versus TMZ for GBM with unmethylated MGMT.
https://clinicaltrials.gov/ct2/show/NCT02617589
The other is testing standard of care plus either nivolumab or placebo.
https://clinicaltrials.gov/ct2/show/NCT02667587
The third checkpoint inhibitor trial is recruiting in Quebec for newly diagnosed GBM, testing avelumab (a PD-L1 antibody).
https://clinicaltrials.gov/ct2/show/NCT03047473
These are the only immunotherapy trials currently recruiting in Canada that I'm aware of, and only one of them is for recurrent GBM.
Stephen, Thanks.
ReplyDeleteBest Regards
James Zhou
James -
ReplyDeleteI investigated the very same question last year when my cousin was being tested for GBM. There was only one neuro-oncologist in Vancouver and so there just isn't the research capacity there that is available in Toronto.
Margaret
mstix:
ReplyDeleteI agree with you. Limited sources in Vancouver
James Zhou