The IDH1 mutation is "heterozygous", meaning only one of the two copies of the IDH1 gene in each cell is mutant, and the other is wild-type. There are cases where the mutant copy of IDH1 gets deleted at recurrence, leaving behind only the wild-type copy, but as I said above this is a relatively rare occurrence.
https://www.ncbi.nlm.nih.gov/pubmed/28916733 Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1
Yes, this is possible, but rare.
ReplyDeleteThe IDH1 mutation is "heterozygous", meaning only one of the two copies of the IDH1 gene in each cell is mutant, and the other is wild-type. There are cases where the mutant copy of IDH1 gets deleted at recurrence, leaving behind only the wild-type copy, but as I said above this is a relatively rare occurrence.
https://www.ncbi.nlm.nih.gov/pubmed/28916733
Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1