Hi All
I hope All are good
My mother Diagnosed with Glioblastoma 2/8/2018
The previous Mri on 30/12/2018 Showd that there is two new tumors
The first one 3.4 x 2.5 x
3.5 cm the second one nearest the first one but it is small 0.7 cm
We started Daily Temodal on 08 /01/2019 with Drug cocktail
Temodal 60 mg daily
Celbrex 400mg daily
Chloroquine 250 mg daily
Prozac 20 mg daily
keppra 2000 daily
Depakine 1000 daily
We start DCA for second time before 6 days 500 daily
And all Supplements
The latest Mri on 20/2/2019 Showed
The biggest tumor shrinking to 2.3 x2.5x3.5cm
the smallest one increased from 0.7 to 1cm
What are you suggesting now going with SRS + Avastin Or continuing with Temodar and adding the remaining drugs?
Why one tumor is shrinking and another one increasing?
Is there any benefit if we continuing Temodal??
Is there any chance for second surgery after 7 months of first surgery?she is walking ,eating,doing every thing normally without any problem..
Please help
Thanks
Modar
I don't see any reason to stop metronomic Temodar. Why not do radio surgery (both tumors probably small enough for this), and then continue with Temodar and add Avastin?
ReplyDeleteI do think metronomic Temodar could have anti-angiogenic effects that could work well with Avastin.
I can't comment on surgery, because that is something that has to be evaluated by the surgeon, and each surgeon might have a different opinion.
It's possible that one of the tumors is resistant to Temodar and one of them still has some sensitivity. Tumors in different locations may have undergone different genetic and epigenetic evolution, so can have different responses to the same treatment.
Thanks for quick reply Stephen
DeleteWe seen two surgeon and both said we can going with surgery if we want
Also Radiation Oncologist say we can go with Srs + Avastin
We will see our Oncologist on Monday after tumor board to discuss with him
If you are in our situation what you will choice?
Surgery?Radiation?Continuing metronomic Temodar with Avastin?
Thanks
My choice would be some sort of local therapy (either conventional surgery or radio surgery), as well as continuing metronomic Temodar and adding Avastin. I'm not sure whether I would choose conventional surgery or radio surgery. It depends on how risky the surgery would be and expected impact on quality of life etc.
Delete