Avastin injection into the spinal canal. PVSRIPO.

• Dear Stephen! Dear all!
  
  Question # 1. Avastin
  
  One oncologist told me that there is a practice in Europe of Avastin injection not into the general bloodstream, but into the spinal canal. And that this technique has shown much better results.
  However, I cannot find any articles or clinical trials on this topic. Please help me, as our team of oncologists is ready to reproduce this.
  Unfortunately, absolutely not clear for me and our team:
  1) How many ml of Avastin should be injected into the spinal canal if we inject 600 ml into the general bloodstream (once every 2 weeks)? Our oncologist is talking about dose reduction, but it is only his assumption.
  2) Would it really be effective in the case of glioblastoma, given that it is located just next to the ventricles?
  3) Could we use standard Avastin or some other “special” Avastin, which is more purified?
  
  Please share any information, links to articles and researches on this issue!
  
  Question # 2. PVSRIPO
  
  Due to the fact that Duke will not take us to clinical trials of PVSRIPO (size of the tumor and absence of insurance), I chose Germany. However, I want to be sure that their methodology is the same as in Duke.
  4) How much virus is introduced in Duke? In the first phase of clinical trials (https://clinicaltrials.gov/ct2/show/NCT01491893?term=..)
  there were 5 dosages (maximum - 1.0 x 10 ^ 10), however, I do not understand what dosage they stopped in phase 2 clinical trials (https://clinicaltrials.gov/ct2/show/NCT02986178?term=.. 3)?
  5) Are there any specific tests (blood, tumor analysis) that will show the effectiveness of PVSRIPO in advance for a particular person?
  6) How dangerous is injection of this virus? Our oncologist says that the reaction from the injection is similar to acute encephalitis. Is it true?
  
  Thank you!