A study that caught my attention with impressive results in vivo albeit mice. They inhibited the p-P-Selectin protein to achieve the results. I found many supplements in my research reducing P-Selectin (EGCG, Melatonin, Lipitor, Resveratrol, Boswellia, etc). What was interesting I found is all the drugs tied with P-Selectin all dealt with inflammation. Sure enough, I found diets such as the Paleo, Low Fat, and Mediterranean diets reduced P-Selectin. I also found a study that correlates P-Selectin to cholesterol levels (LDL) as well as inflammatory responses to exercise.
Study:
https://www.timesofisrael.com/israeli-scientists-stop-brain-tumors-in-mice-say-may-cure-a-deadly-cancer/?fbclid=IwAR0mxsbykw5w5mE33zAgUCO1x3cn6BRXAQjZ5Jb_F3w255JltJ60FcEhQNw
Diet impact:
https://pubmed.ncbi.nlm.nih.gov/11412051/
Impact of Edema:
https://pubmed.ncbi.nlm.nih.gov/10670575/
Exercise and LDL correlation of P-Selectin:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590908/
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