Does anyone have any knowledge of mTOR inhibitors and availability?
I am looking into them as a target for MYCN amplification due to the
H3F3A G34r mutation that my daughter has.
We have today had recurrence confirmed in inoperable areas and are trying to decide what may be the best way forward.
There don't seem to be a lot of options with this mutation.
Showing posts with label mTOR. Show all posts
Showing posts with label mTOR. Show all posts
Monday, 22 August 2016
Saturday, 12 September 2015
Fluoxetine, another MGMT inhibitor?
Important new study here which I will summarize on Astrocytoma Options when I have the chance. Looks like we might be able to add fluoxetine (Prozac) to the list of agents (along with Keppra and disulfiram) that potentially inhibit MGMT activity in brain tumors and sensitize those tumors with unmethylated/active MGMT to TMZ/CCNU/BCNU. The main limitations of this study are that the tumor cells were injected into the mouse flank (not into the brain), the drug was injected intraperitoneally (not given orally), and the mice were nude (immunodeficient) mice, so potential effects of fluoxetine on the immune response were not taken into account.
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