What to avoid during stable period

Sorry for repeating my earlier question, but I thought a broader category would help get us talking. My question is whether anyone is aware of mechanisms of action of melatonin or metformin that might make them undesirable for a low grade oli with deletions to take during stable period (either them not being efficacious apart from cocktail or might exacerbate mutation)?

The larger topic is; What should be avoided during stable period that might exacerbate mutation?