My mom will soon take next course of Lomustine + 5 days of Temozolomide.
To enhance the effect of this combination only these days we want to take also:
1. Disulfiram 500 mg + Copper 4mg + DHA 1200mg / day
2. Verapamil 300-400 mg / day (doses of 40 mg every few hours, so that blood pressure does not go down much)
3. Curcumin Longvida 2000mg, EGCg 2000mg / day
4. Alfacalcidol 2 mg / day
According to this study: https://www.ncbi.nlm.nih.gov/pubmed/27313664
Autophagy enhancement contributes to the synergistic effect of vitamin D in temozolomide-based glioblastoma chemotherapy.
Are there any other ideas that can enhance the effect? I have not forgotten anything?
Since my mother takes Lomustine and Temozolomide according to the Ceteg trial every 42 days, I do not want to miss anything.
In addition to these additives our main cocktail includes:
1. Delagil 300 mg / day
2. Bevacizumab 7,5mg/kg/3weeks
2. Sirolimus 2 mg / day (possibly, it will be reduced to 1 mg because of Varapamil)
3. Telmisartan 80 mg (will be canceled for this period because of Verapamil)
4. DCA + caffeine (will be canceled for this period because of Disulfiram)
5. Inhalation with perillic alcohol (will be canceled for this period because of Disulfiram).
- After Disulfiram, when we can start inhalation again? Probably need a break.
- Perhaps, for the effect of Disulfiram it is necessary to take it constantly, and not only in the days of Lomustine + Temozolomide? Perhaps, Disulfiram will not have an effect only in these 6 days?
____________________________
I also found this research:
Lithium enhances the antitumour effect of temozolomide against TP53 wild-type glioblastoma cells via NFAT1/FasL signalling.
2017 https://www.ncbi.nlm.nih.gov/pubmed/28359080
"Temozolomide combined with low-dose Li induces TP53wt glioma cell death via NFAT1/FasL signalling. This represents a potential therapeutic strategy for TP53wt glioma treatment."
However, I can not understand is the wild type TP53 our case?
http://btcocktails.blogspot.ru/2018/02/our-report-oncodeep-what-do-you.html
To enhance the effect of this combination only these days we want to take also:
1. Disulfiram 500 mg + Copper 4mg + DHA 1200mg / day
2. Verapamil 300-400 mg / day (doses of 40 mg every few hours, so that blood pressure does not go down much)
3. Curcumin Longvida 2000mg, EGCg 2000mg / day
4. Alfacalcidol 2 mg / day
According to this study: https://www.ncbi.nlm.nih.gov/pubmed/27313664
Autophagy enhancement contributes to the synergistic effect of vitamin D in temozolomide-based glioblastoma chemotherapy.
Are there any other ideas that can enhance the effect? I have not forgotten anything?
Since my mother takes Lomustine and Temozolomide according to the Ceteg trial every 42 days, I do not want to miss anything.
In addition to these additives our main cocktail includes:
1. Delagil 300 mg / day
2. Bevacizumab 7,5mg/kg/3weeks
2. Sirolimus 2 mg / day (possibly, it will be reduced to 1 mg because of Varapamil)
3. Telmisartan 80 mg (will be canceled for this period because of Verapamil)
4. DCA + caffeine (will be canceled for this period because of Disulfiram)
5. Inhalation with perillic alcohol (will be canceled for this period because of Disulfiram).
- After Disulfiram, when we can start inhalation again? Probably need a break.
- Perhaps, for the effect of Disulfiram it is necessary to take it constantly, and not only in the days of Lomustine + Temozolomide? Perhaps, Disulfiram will not have an effect only in these 6 days?
____________________________
I also found this research:
Lithium enhances the antitumour effect of temozolomide against TP53 wild-type glioblastoma cells via NFAT1/FasL signalling.
2017 https://www.ncbi.nlm.nih.gov/pubmed/28359080
"Temozolomide combined with low-dose Li induces TP53wt glioma cell death via NFAT1/FasL signalling. This represents a potential therapeutic strategy for TP53wt glioma treatment."
However, I can not understand is the wild type TP53 our case?
http://btcocktails.blogspot.ru/2018/02/our-report-oncodeep-what-do-you.html
"Wild type" simply means "not mutant". In your mom's case it seems there is likely one mutant copy of TP53 with a "damaging" frameshift mutation and one wild-type non mutant copy. The mutant copy was found at a frequency of 58%, so the other 42% of reads must have been wild type. I would not call your mom's tumor TP53 wild type because of the frameshift mutation found at a frequency of 58%.
ReplyDeleteThank you, Stephen!
ReplyDelete------
After long hours of reflection, I decided not to take Desulfiram + Copper. Probably, it will not be useful for short-term admission.