Unmethylated treatment advice

Hi,
My beautiful husband had removal of GBM left parietal tumour last October.
Histopatholgy results:

The sections show multiple fragments of hyper cellular brain parenchyma, diffusely infiltrated by tumour composed of hyper chromatic and atypical glial cells, set in a fibrillary background.   The glial cells have a broad morphological spectrum which includes scattered epitheloid forms with abundant pink cytoplasm and smaller glial cells with a high nuclear to cytoplasmic ratio. Frequent mitotic figures are present including atypical forms. Multiple foei of palisading tumour necrosis and microvascular proliferation are seen.

ATRX: retained 

IDH1 (r13211) immunonegative

EGFR; strongly and diffusely positive

P53: positive in approximately 30% of the tumour cells

Ki67 prolification index: approximately 20%

Unmethylated 

Glioblastoma IDH-wild type grade 4 

After surgery we have commenced veliparib  + radiology.

We are now on a break and due to commence veliparib + temozolomide in about a week (6 month treatment:one week on tablets ; three weeks off)

Current supplements

Curcumin 

Silymarin 

PSK

Selenium 

Vitamin D

Multivitamin 

+ Ketogenic diet 

Because we live regionally (in Australia), we are now assigned a local oncologist (not neuro-oncologist).  This VERTU trial is the only offered treatment.  The oncologist is reluctant to discuss other options/supplements.

The registered nurse overseeing the trial said that if I approached the doctor and asked to add a medication they would consider it, so we have an appointment next week that I have an opportunity to put a case forward for other treatment, hence I am asking for advice.

Question: should we be pushing for Keppra?  

Question: should we be looking for other treatment... I am not hearing much of anyone on veliparib.

Question: Please advise if it would be beneficial to add artemisinin to the supplements, and if so how will that work with the veliparib  + temozolomide 

Question: Do you have any other recommendations for supplements?

Thank you in advance for any assistance.

And I also thank you all for writing on btcocktails  and sharing stories and knowledge... It makes me feel not so alone.

Risperidone

A newly published case study describes the case of a 57-year old GBM patient, with poor prognosis due to a KPS of only 50 and postoperative neurologic symptoms.  The patient was being treated for schizophrenia at the time of GBM diagnosis with risperidone at a dose of 6-6.5 mg per day.  He ended up going 5.5 years without recurrence, and then lived for an additional year after first recurrence.  This paper posits a possible correlation of his unexpected progression-free survival with his use of risperidone.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066542/

In 2010, Richard Kast published a paper hypothesizing that risperidone, pimozide, and paliperidone could be useful for GBM treatment as 5-HT7 serotonin receptor antagonists.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990148/

Additionally, risperidone is a potent inhibitor of D2 and D3 dopamine receptors. D2 has been described as a valid target for GBM therapy:

https://www.ncbi.nlm.nih.gov/pubmed/24658464

Finally, a more recent paper by Richard Kast and Marc Halatsch proposing D3 dopamine receptor as a target for GBM therapy.

https://www.ncbi.nlm.nih.gov/pubmed/24242756