My beautiful husband had removal of GBM left parietal tumour last October.
The sections show multiple fragments of hyper cellular brain parenchyma, diffusely infiltrated by tumour composed of hyper chromatic and atypical glial cells, set in a fibrillary background. The glial cells have a broad morphological spectrum which includes scattered epitheloid forms with abundant pink cytoplasm and smaller glial cells with a high nuclear to cytoplasmic ratio. Frequent mitotic figures are present including atypical forms. Multiple foei of palisading tumour necrosis and microvascular proliferation are seen.
IDH1 (r13211) immunonegative
EGFR; strongly and diffusely positive
P53: positive in approximately 30% of the tumour cells
Ki67 prolification index: approximately 20%
Glioblastoma IDH-wild type grade 4
After surgery we have commenced veliparib + radiology.
We are now on a break and due to commence veliparib + temozolomide in about a week (6 month treatment:one week on tablets ; three weeks off)
+ Ketogenic diet
Because we live regionally (in Australia), we are now assigned a local oncologist (not neuro-oncologist). This VERTU trial is the only offered treatment. The oncologist is reluctant to discuss other options/supplements.
The registered nurse overseeing the trial said that if I approached the doctor and asked to add a medication they would consider it, so we have an appointment next week that I have an opportunity to put a case forward for other treatment, hence I am asking for advice.
Question: should we be pushing for Keppra?
Question: should we be looking for other treatment... I am not hearing much of anyone on veliparib.
Question: Please advise if it would be beneficial to add artemisinin to the supplements, and if so how will that work with the veliparib + temozolomide
Question: Do you have any other recommendations for supplements?
Thank you in advance for any assistance.
And I also thank you all for writing on btcocktails and sharing stories and knowledge... It makes me feel not so alone.