Thursday, 5 January 2017
PLK1, IDH1, and Genistein
Came across this study on sensitizing IDH1 mutant tumors to TMZ. Inhibiting PLK1 sensitized mutant IDH1 gliomas to TMZ in mice.
PLK1 INHIBITION ENHANCES TEMOZOLOMIDE EFFICACY IN IDH1 MUTANT GLIOMAS
They used the small molecule BI2536 which is not currently available outside of clinical trials. However, I did find a 2016 study on Genistein (which is available retail) and its possible inhibition of PLK1.
Sensitivity of TP53-Mutated Cancer Cells to the Phytoestrogen Genistein Is Associated with Direct Inhibition of Plk1 Activity.
Some more info on Genistein here as well.