Hello all, I just also reviewed this 1/17/2017 article regarding GBM and Chloroquine (https://www.sciencedaily.com/releases/2017/01/170117084050.htm) and there seems to be some efficacy with Chloroquine use in BRAF mutation positive GBM. In our case the BRAF mutation was not detected and I'm wondering if CQ would still have a place in our cocktail in the absence of this mutation.
However, as was pointed out on this blog, retrospective studies have indicated Chloroquine as being particularly effective in
EGFRvIII positive GBM, which is the case with our GBM. I also noted clinical trials going on using CQ in GBM, but could not find any prelim data. We just finished cycle 2 of TMZ and want to add Chloroquine to our cocktail right away.
Does anyone have an idea regarding the dose (mg) and how it should be taken? (one a day? twice a day? only during the 5/28? Regards,
Stephen W edited this post to include the following image: