Wednesday, 25 January 2017

My niece keep fighting with GBM. Last 3er January  did new MRI and we are waiting for the result but with the hope that the MRI were well (for some anticipated information)  ..
She has GBM no methilated and we think that temodar is not so effective in this cases. She had a second operation after first operation and treated with temodar. We read about Avastin that is very hopeful.

She started taking a non toxic cocktail of drug (curcumine, fish oil, Melatonina, PSK, Spirulina, Green te, vitamin C, D3,K2, resveratrol, etc) and Savitex with THC y CBD. She doesn't have any medical supervision about the cocktail. After a radioteraphy and little period of rest, she again is taking chemotherapy (temodar) and we think to add others drug (a little bit more toxic) that we read are good to fight against tumors, but we are scared about its interactions. We think to add Chloroquine and Celebrex (celecoxib). 

Do you think it’s a good option to join THC and CBD with Chloroquine and Celebrex?. I read about the moderate interactions between Chloroquine and Celebrex, but I didn’t read anything clear for me about THC/CBD and Chloroquine or Celebrex.
Please could you help us about your experiences? We would appreciate any  information. Thank you very much.

Sincerely, Jose Mª



  1. I take THC and CBD oils and Celebrex is part of my cocktail. I have no negative experiences that I can correlate to the THC/CBD and Celecbrex. I did talke Chloroquine for a while as well but not any more. No issues when I was taking it. I do not take it anymore since I am no longer on Temador.

  2. Unfortunately the drug interactions database that I usually use, which is the Cerner Multum database available for free at, doesn't include non-prescription supplements. Dronabinol is in the database, and is a synthetic version of THC available by prescription. There is no information on interactions between dronabinol and chloroquine or Celebrex, which usually means that no interactions have been reported in the literature.

  3. Thank you Stephen and Marc. Recently I have found and article relate a treatment with Δ(9)-Tetrahydrocannabinol (THC) and chloroquine but for me, this article is very specialized and I don’t understand very well the conclusion. It seem that chloroquine could inhibit the effect of THC? Please see attach the link:

    Rhank you very much!

    1. The chloroquine result in this study is a little hard to interpret. Chloroquine treatment of cells in this study was actually increasing the expression of LC3-II (a marker of autophagy) when combined with THC. This is shown in figure 3b. Yet in figure 3c, the reduction in cell viability was somewhat less when chloroquine was added to THC, versus THC alone.

      I have a problem accepting the results of in vitro studies as I explained in a recent post.( ) That is because the activity of drugs on cells is usually dose-dependent and the drug concentrations used in vitro are usually unrealistically high, as they are in this study.

      I would trust the in vivo (rodent) data more, but chloroquine + THC/Sativex were not combined in the in vivo part of this study.

      Furthermore, studies with cannabinoids in vivo in immunosuppressed (athymic) mice aren't that trustworthy either. There was a study a while back showing that high dose THC injection improved mouse survival in athymic mice, but decreased mouse survival in immunocompetent mice, through an immunosuppressive mechanism in those particular models (which were lung and breast cancer models). This is likely more of an issue for immunogenic tumors where there is some effective immune activity going on independently of treatments.

      Unfortunately what I'm trying to say is that the in vitro conclusions of this study do not necessarily tell us much about what happens in humans with a completely different type of cancer. The conclusions of any study are particular to the conditions of that study and the model system used. If this study had shown that chloroquine and THC were antagonistic in the mice, it would have been somewhat more compelling, as far as avoiding that combination.