That is interesting. I was just at the MGH yesterday going over my wife's next regimen to treat her 1st GBM reocurrence. It was a big deal that they were willing to go with the TMZ and CCNU combo having seen the research presented at SNO for newly diagnosed.
Being already in use a long time for other cancers - would it be worthy, based upon this initial research, to push to add Hydroxyurea to my wife's regimen? There's no doubt there would be tremendous push back because of the unknowns with this mix -- but we all know what we are up against with this disease and our ongoing push to get the Onco community to loosen up their shirt collars and take some bleeping "risks".
I would love to get your thoughts on this and if I should push for this.
You might be able to convince an oncologist to combine TMZ with hydroxyurea, and this is also being studied in a new trial. https://clinicaltrials.gov/ct2/show/NCT03463733
But I agree that there's very few "cowboys" out there that would be willing to risk TMZ + CCNU + hydroxyurea, without any clinical precedent for this combination. There was an old trial that combined hydroxyurea + radiation, followed by BCNU plus 6-thioguanine. https://www.ncbi.nlm.nih.gov/pubmed/9422558
What I don't understand is why this hydroxyurea mouse study is getting so much publicity. I could think of numerous similar mouse studies that just get buried away in scientific journals and nobody ever hears about them or publishes news stories about them.
That is interesting. I was just at the MGH yesterday going over my wife's next regimen to treat her 1st GBM reocurrence. It was a big deal that they were willing to go with the TMZ and CCNU combo having seen the research presented at SNO for newly diagnosed.
ReplyDeleteBeing already in use a long time for other cancers - would it be worthy, based upon this initial research, to push to add Hydroxyurea to my wife's regimen? There's no doubt there would be tremendous push back because of the unknowns with this mix -- but we all know what we are up against with this disease and our ongoing push to get the Onco community to loosen up their shirt collars and take some bleeping "risks".
I would love to get your thoughts on this and if I should push for this.
You might be able to convince an oncologist to combine TMZ with hydroxyurea, and this is also being studied in a new trial.
Deletehttps://clinicaltrials.gov/ct2/show/NCT03463733
But I agree that there's very few "cowboys" out there that would be willing to risk TMZ + CCNU + hydroxyurea, without any clinical precedent for this combination. There was an old trial that combined hydroxyurea + radiation, followed by BCNU plus 6-thioguanine.
https://www.ncbi.nlm.nih.gov/pubmed/9422558
What I don't understand is why this hydroxyurea mouse study is getting so much publicity. I could think of numerous similar mouse studies that just get buried away in scientific journals and nobody ever hears about them or publishes news stories about them.