I'm new to the blog and blogging in general. My brother is 3 weeks post op craniotomy for removal of 2cm brain tumor in left frontal lobe - complete resection was not possible but approximately 80% removed. Otherwise Joe is a healthy 35 yo male
Pathology report came back:
Grade IV Glioblastoma, wild type
Negative MGMT methylation
No amplification of EGFR gene
He will be part of a clinical trial with proton therapy radiation at MGH in Boston. Joe is gripped by depression but committed to starting treatment - hopefully along with a drug cocktail. I've been helping him research and pull it together. When he starts radiation and chemo in a week or so I would like him to be on below meds / supplements
This is not a complete outline as I'm using some supplements he purchased and some meds he is already on (valproic acid). I would love to have any suggestions or thoughts.
I also have some questions for you all (I'm sure the first of many)
1. How open are neuro oncologist to a cocktail approach? Joe is afraid of asking them about adding anything to the current standard of care
2. Is it true that unmethylated MGMT tumors are not as responsive to TMZ? Should we ask about a metronomic everyday low dose? What is the current dosing of TMZ in standard of care?
3. Should we look into adding Antabuse, Metformin, or an ACE Inhibitor?
*my apologies for any typos