Monday, 17 December 2018

Retinoic acid for reversing immune evasion in IDH-mutant gliomas

I'm still going through the abstracts from this year's SNO meeting and came across this:

https://academic.oup.com/neuro-oncology/article-abstract/20/suppl_6/vi258/5154118
EFFICACY OF RETINOIC ACID IN REVERSING IMMUNE EVASION IN IDH MUTANT GLIOMAS

It's tempting to speculate that Ben Williams' use of Accutane (another form of retinoic acid - namely 13-cis retinoic acid) was part of the reason for his excellent response back in 1995. His tumor was since found to be IDH1-mutant. 

This study used ATRA, or all-trans retinoic acid.

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