Monday 13 May 2019

Clemastine-treatment - Exploiting a Chink in the Armour of Glioblastoma Cells

https://www.technologynetworks.com/cancer-research/news/exploiting-a-chink-in-the-armor-of-brain-tumor-cells-319276

4 comments:

  1. Very interesting, thank you!

    But what dosage of the drug should be taken?

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  2. The mice were given intraperitoneal (abdominal) injections of clemastine at doses of 100 mg/kg (day 1) and 50 mg/kg (day 2 - 13).

    This would translate (using allometric scaling formulas) to approximately 8 mg/kg and 4 mg/kg for a human, or 480 mg and 240 mg for a human weighing 60 kg.

    HOWEVER, drugs.com says the maximum adult dose for allergic rhinitis, urticaria, and allergic reaction should not exceed 2.68 mg three times daily (approx 8 mg per day).
    https://www.drugs.com/dosage/clemastine.html

    So apparently the doses given to the mice were mega-doses compared to standard human doses. I wouldn't want to experiment with doses much higher than the standard recommended human doses without some kind of human evidence of safety for higher doses.

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  3. Thanks, Stephen, for this important info. Here is another article on a related basis of Repurposing that is specific about Non Sm all Cell Lung Cancer, BUT has referenced multiple antihistamines
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972561/ "Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment"

    It specifically references Clemastine for a Higher Hazard Ratio of 40%.

    The bright spot is the connection to Loratadine, for the same reasons described in the above Finnish study i.e. " inducers of lysosomal cell death."
    What do you think?

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  4. It's always mega doses given to the mice :( I've been trying to do the calculation from the study, I'm happy I remembered to do a search here. Thanks Stephen for making my morning easier!

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