The mice were given intraperitoneal (abdominal) injections of clemastine at doses of 100 mg/kg (day 1) and 50 mg/kg (day 2 - 13).
This would translate (using allometric scaling formulas) to approximately 8 mg/kg and 4 mg/kg for a human, or 480 mg and 240 mg for a human weighing 60 kg.
HOWEVER, drugs.com says the maximum adult dose for allergic rhinitis, urticaria, and allergic reaction should not exceed 2.68 mg three times daily (approx 8 mg per day). https://www.drugs.com/dosage/clemastine.html
So apparently the doses given to the mice were mega-doses compared to standard human doses. I wouldn't want to experiment with doses much higher than the standard recommended human doses without some kind of human evidence of safety for higher doses.
Thanks, Stephen, for this important info. Here is another article on a related basis of Repurposing that is specific about Non Sm all Cell Lung Cancer, BUT has referenced multiple antihistamines https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972561/ "Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment"
It specifically references Clemastine for a Higher Hazard Ratio of 40%.
The bright spot is the connection to Loratadine, for the same reasons described in the above Finnish study i.e. " inducers of lysosomal cell death." What do you think?
It's always mega doses given to the mice :( I've been trying to do the calculation from the study, I'm happy I remembered to do a search here. Thanks Stephen for making my morning easier!
Very interesting, thank you!
ReplyDeleteBut what dosage of the drug should be taken?
The mice were given intraperitoneal (abdominal) injections of clemastine at doses of 100 mg/kg (day 1) and 50 mg/kg (day 2 - 13).
ReplyDeleteThis would translate (using allometric scaling formulas) to approximately 8 mg/kg and 4 mg/kg for a human, or 480 mg and 240 mg for a human weighing 60 kg.
HOWEVER, drugs.com says the maximum adult dose for allergic rhinitis, urticaria, and allergic reaction should not exceed 2.68 mg three times daily (approx 8 mg per day).
https://www.drugs.com/dosage/clemastine.html
So apparently the doses given to the mice were mega-doses compared to standard human doses. I wouldn't want to experiment with doses much higher than the standard recommended human doses without some kind of human evidence of safety for higher doses.
Thanks, Stephen, for this important info. Here is another article on a related basis of Repurposing that is specific about Non Sm all Cell Lung Cancer, BUT has referenced multiple antihistamines
ReplyDeletehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972561/ "Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment"
It specifically references Clemastine for a Higher Hazard Ratio of 40%.
The bright spot is the connection to Loratadine, for the same reasons described in the above Finnish study i.e. " inducers of lysosomal cell death."
What do you think?
It's always mega doses given to the mice :( I've been trying to do the calculation from the study, I'm happy I remembered to do a search here. Thanks Stephen for making my morning easier!
ReplyDelete