Repurposing Chlorpromazine in the Treatment of Glioblastoma (RACTAC)
https://clinicaltrials.gov/ct2/show/NCT04224441
This is a phase 2 trial being conducted in Italy.
Two interesting points to remember:
Chlorpromazine is an old off-patent drug, in clinical use since the 1950s.
Like the new drug ONC201 (which is in several trials and an expanded access program for H3 K27M mutant gliomas and DIPG), it is an antagonist of dopamine receptor D2 (DRD2).
Feb 5 2020 edit:
See also
https://www.ncbi.nlm.nih.gov/pubmed/32005270
Repurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps.
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