https://www.ncbi.nlm.nih.gov/pubmed/32060760
Safety aspects of opioid-naïve patients with high-grade glioma treated with D,L-Methadone: an observational case series.
from the abstract:
"Twenty-four patients were included. All patients were opioid-naïve and received D, L-Methadone from their general practitioners. Sixteen patients experienced side effects. The median dosage when side effects began to occur was 15.8 mg/ 24 h. Fatigue and mood changes were reported most frequently (14 of 24 patients). Five patients had severe side effects related to relatively high doses. In all cases, symptoms resolved after cessation or dose reduction. Our results show that D/L M intake lead to frequent occurrence of side effects in opioid-naïve patients especially when not handled with caution and close supervision. Patients, their relatives, their GPs and neuro-oncologists need to be informed about the broad spectrum of side effects in order to thoroughly counsel glioma patients."
Hi all,
ReplyDeletemost important thing is to be patient in terms of increasing the dose.
There are recommandations how many drops to take on day 1,2,3... In my experience this doesn`t work for everybody.
If the side effects are to strong like hallucinations, scratchig etc. you shouldn`t further increase the dose instead taking the acutal dose for 2 or 3 days and then go on or even lower the dose about 1 or 2 drops.
After that you should increase slowly, in a way you can handle the side effects.If it is not possible for you to reach the recommendet targed dose just take a few drops less. Maybe you can increase further after some weeks.
All the best!