This was just published a few days ago in Science Translational Medicine.
Control of brain tumor growth by reactivating myeloid cells with niacin
Sarkar et al.
https://stm.sciencemag.org/content/12/537/eaay9924.editor-summary
"Although innate immune cells are typically present inside tumors, they often have an inactive phenotype such that they are ineffective at killing the cancer cells or even promote tumor growth. Sarkar et al. discovered that it may be possible to reprogram these cells to a more active type using niacin (vitamin B3). The authors showed that niacin-exposed monocytes can inhibit the growth of brain tumor–initiating cells. Moreover, niacin treatment of intracranial mouse models of glioblastoma increased monocyte and macrophage infiltration into the tumors, stimulated antitumor immune responses, and extended the animals’ survival, especially when combined with the chemotherapeutic drug temozolomide."
I have uploaded the full study to the Brain Tumor Library, follow this pathway:
Folder 0. Important Reference documents -> subfolder 1. New Uploads -> "2020 Sarkar Niacin reactivates myeloid cells"
Interesting article, thanks for sharing. It seems that niacin was injected into mice into their abdominal cavity (intraperitoneal) and I wonder whether niacin may have any useful anticancer role when taken orally and combined with temozolomide? Are there other studies suggesting improved outcomes with nutritional niacin, I wonder?
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