https://sci-hub.tw/https://www.redjournal.org/article/S0360-3016(20)31308-0/pdf (full PDF from sci-hub)
https://www.redjournal.org/article/S0360-3016(20)31308-0/pdf (link to journal abstract, full PDF requires a payment)
Half the patients were randomized to re-irradiation plus standard diet (SD), the other half were randomized to re-irradiation plus ketogenic diet plus intermittent fasting (KD-IF).
- PFS6 was not significantly different between the two groups (KD-IF: 20%, SD: 16%).
- Similarly, no difference in PFS, local PFS6 and OS was observable.
- Explorative analysis revealed that patients of the KD-IF group who had a glucose of less than the median (83.5 mg/dl) on day 6 had a significantly longer PFS and OS compared to those above the median