Wednesday, 23 December 2020

Intranasal perillyl alcohol + low carbohydrate diet

 Adjuvant effect of low-carbohydrate diet on outcomes of patients with recurrent glioblastoma under intranasal perillyl alcohol therapy

"Results:

In the 1-year follow-up, the POH/LCD group showed a 4.4-fold decrease in the proportion of patients who needed treatment with corticosteroids, as well as a reduction in tumor size and peritumoral edema, as compared to the POH group. While 75% of patients undergoing POH treatment experienced seizures, this fraction was reduced to 56% in the POH/LCD group. A 2.07-fold increase in the proportion of patients with stable disease, along with a 2.8-fold decrease in the proportion of patients with TP, was seen in the POH/LCD group."


POH = intranasal perillyl alcohol

LCD = low carbohydrate diet

TP = tumor progression.


View full study here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7710475/


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