Quick question: which is proven to be more effective in overcoming BBB for agents to go into the tumor -- Prozac or Viagra or Selegiline? I have seen many people including Prozac in their cocktail. However, Ben Williams probably indicated in his latest PDF that selegiline could be more effective. Any insights to help select one? thanks, Jinesh
The idea that selegiline might be useful to open up the blood-brain barrier comes from a 2010 paper by Richard Kast, one of the main authors of the CUSP9 protocol.
ReplyDeletehttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822451/
"Clinically significant amounts of methamphetamine are circulating in patients currently treated with selegiline [37,38]. Is that level enough to decrease BBB integrity? This matter requires urgent study."
As far as I know, no such study has been carried out, and the potential effect of selegiline on blood-brain barrier is still hypothetical.
The evidence for fluoxetine (Prozac) or sildenafil (Revatio, Viagra) is only slightly better, and comes from rodent studies.
Sildenafil has reached clinical trials as a blood-brain barrier disrupting agent, but the trial is still underway and I haven't heard any results yet.
https://clinicaltrials.gov/ct2/show/NCT01817751
Fluoxetine has shown direct single agent anti-glioma activity in two glioma mouse models (not related to effects on blood-brain barrier), and sildenafil has beneficial immune effects as an inhibitor of immune suppressor cell activity (also unrelated to effects on blood-brain barrier), also shown in rodent models.
I would rank both fluoxetine and sildenafil higher than selegiline because of superior literature support as well as multiple mechanisms of action beyond effects on the blood-brain barrier.
Hi Stephen,
ReplyDeleteThank you. Which one would you go for between the two - Viagra or Prozac?