Which clinic you or your loved one sought treatment at?
What stage of illness you sought treatment (post-surgery, post-recurrence)?
Whether treatment was effective and if so for how long?
What the clinic used to produce the vaccine (fresh sample, paraffin sample, blood sample, etc...) .
Clinics I have begun looking into include: IOZK, Unifontis/Dr. Drevs, Hallwang, NextGen Oncology, CeGat and Praxisgemeinschaft/Dr. Nesselhut.
I am seeking treatment for my husband who is 53 yo. We live in the U.S. and have 2 children. This is my first time posting and I want to express my immense gratitude to all who have posted. It has been an incredibly helpful and sustaining resource. My heartfelt compassion to all of you.
I have spoken with investigators at some of the clinics, but I do not have personal experience beyond my conversations.
ReplyDeleteWhich clinic you or your loved one sought treatment at?
Of those you listed, I have only encountered negatives (on websites) for the Hallwang clinic. Indirect info, so it might be good to research
Praxisgemeinschaft/Dr. Nesselhut - presented at ASCO, good data
IOZK - viral/peptide vaccine, interesting approach
NextGen - less communicative but produces a very good, highly-specific neoantigen vaccine
Unifontis - heard this is administered through the skin vs. cells, some argue this is less promising (major debate)
CeGat - good for sequencing, likely could make a neoantigen vaccine
Hallwang - not sure about their vaccine or quality level
What stage of illness you sought treatment (post-surgery, post-recurrence)?
Thought to work better when used sooner and with less disease (as a preventative)
Whether treatment was effective and if so for how long?
These are thought to help lots of patients by building immune response, potentially improving follow-up therapy. However, these are really controversial and might only help a smaller groups of patients. For this reason, they have trouble passing trials.
What the clinic used to produce the vaccine (fresh sample, paraffin sample, blood sample, etc...) .
Many of these can use lab-generated peptide vaccines mixed with immune cells. Fresh tumor is preferred by some but requires special preservation during surgery.
Hope this helps!
My mother is having vaccines and virus (Newcastle disease virus) at iozk. She was diagnosed 3 years ago, 1 recurrence, she is very tired but she is here and doing well. They use dendritic cells vaccine after the viral infection and hyperthermia. Some patients have a good results, not everybody unfortunatly
ReplyDeleteIOZK uses multimodal immunotherapy consisting of injections of Newcastle disease virus (NDV, an oncolytic virus) + modulated electrohyperthermia (mEHT) + autologous mature DC vaccines loaded with protein tumor antigens + immunomodulatory strategies. NDV/mEHT induce immunogenic cell death of tumor cells, and this can already be combined during Temozolomide maintenance chemotherapy (which is a genetic mode of tumor cell killing). DC vaccines are placed after the chemotherapy maintenance (because chemotherapy affects proliferating immune cells). Further continuation of treatment is then performed with NDV/mEHT maintenance immunotherapy. A paper on this concept is just published in Austin Oncology Case Reports.
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