Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization
(clicking on the study title will send you to the article)
This was an intracranial (orthotopic) glioma mouse model, using human glioma initiating cells injected into nude mice. The mice were treated with fluvoxamine, an anti-depressant, by intraperitoneal injection, which improved mouse survival somewhat. The study is mainly interesting as I haven't seen this drug used in vivo in cancer models before.
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