Has anyone been involved or know anything about this trial https://clinicaltrials.gov/ct2/show/NCT02152982. Methylation is required but unfortunately it's includes a randomized 50% placebo factor -- I am not a fan of rolling those dice.
I participated in this trial for 6 cycles. I did drop out at the end so I could continue TMZ.
I actually did better on the Veliparib and TMZ together than I have on just TMZ. Since I have stopped Veliparib, at the end of the TMZ cycles, I break out in hives for two days.
One consideration in participating in such trials is that, should the intervention be found beneficial, it is common that all participants are then provided the active agent. No guarantee of that, but it's commonly done.
Another consideration mitigating the downside of being in the placebo arm is that, after the trial, the placebo recipients would likely remain eligible for other clinical trials, while the active arm might not qualify.
Does anyone know anything about this veliparib trial? And what supplements may suit it? VERTU: Veliparib, radiotherapy (RT) and temozolomide (TMZ) trial in unmethylated MGMT glioblastoma (GBM).
Veliparib is a PARP inhibitor. PARP is a DNA damage repair enzyme involved in base excision repair. PARP inhibitors are often used ovarian cancer with BRCA mutations, as the combination of PARP inhibition with the lack of double strand break repair due to BRCA1 or BRCA2 mutations is especially effective.
Whether or not PARP inhibitors will be effective in an entirely different context (GBM) is what this trial is trying to determine.
In mouse models, the TMZ-sensitizing effect of veliparib was dependent on MGMT status. In other mouse models, some agents that have been able to suppress or downregulate MGMT are: levetiracetam/Keppra, fluoxetine/Prozac, and disulfiram, so patients with MGMT-unmethylated GBM could theoretically benefit from such treatments. https://www.ncbi.nlm.nih.gov/pubmed/26615020
Yes, the most recent result is here: https://www.ncbi.nlm.nih.gov/pubmed/27803064
This was a trial for advanced lung cancer. 2/3rds of the participants got carboplatin + paclitaxel + veliparib and 1/3 got carboplatin + paclitaxel plus placebo (158 patients in total).
The veliparib arm had a trend towards improved PFS and overall survival but the differences didn't reach formal statistical significance.
Of course this trial can't predict how well it will work for a completely different type of cancer added to a completely different chemo regimen.
The more I read the more I'm overwhelmed. In this trial my husband has been given veliparib not placebo. This is his histopatholgy post surgery removal left parietal tumour ATRX: retained IDH1 (r13211) immunonegative EGFR; strongly and diffusely positive P53: positive in approximately 30% of the tumour cells Ki67 prolification index: approximately 20% Glioblastoma IDH-wild type WIIO (2016) grade 4 I'm having difficulty working out what all the above means. I think IDH wild type unmethalated must be extremely aggressive? He is in last week radiotherapy I have had no help understanding what extra products to give as all the advise is to "continue the trial treatment." I have had no help understanding what extra products to give as all the advise is to "continue the trial standard treatment " This is what I have put together and would like some feedback if this is ok? He is on ketogenic diet. Flax oil with cottage cheese (x4 tablespoon daily) Fish oil 1000mg (x2 daily) Boswellia topical oil (rubbed on head + inhaled) Vitamin c 1g (x2 daily) Lyphodran Plus: Quercetin 500mg / Rutin 400mg / Bromelains 125mg / absorbing Acid 50mg (x3 daily) I have just bought... Borage seed oil 1000mg Selenium 200mcg I have these meds on order... PSK Melatonin Not sure if anything counteracts each other or is harmful or what dosages to give. Any any advice is welcome
I participated in this trial for 6 cycles. I did drop out at the end so I could continue TMZ.
ReplyDeleteI actually did better on the Veliparib and TMZ together than I have on just TMZ. Since I have stopped Veliparib, at the end of the TMZ cycles, I break out in hives for two days.
Marc
One consideration in participating in such trials is that, should the intervention be found beneficial, it is common that all participants are then provided the active agent. No guarantee of that, but it's commonly done.
ReplyDeleteAnother consideration mitigating the downside of being in the placebo arm is that, after the trial, the placebo recipients would likely remain eligible for other clinical trials, while the active arm might not qualify.
Does anyone know anything about this veliparib trial? And what supplements may suit it?
ReplyDeleteVERTU: Veliparib, radiotherapy (RT) and temozolomide (TMZ) trial in unmethylated MGMT glioblastoma (GBM).
Veliparib is a PARP inhibitor. PARP is a DNA damage repair enzyme involved in base excision repair. PARP inhibitors are often used ovarian cancer with BRCA mutations, as the combination of PARP inhibition with the lack of double strand break repair due to BRCA1 or BRCA2 mutations is especially effective.
DeleteWhether or not PARP inhibitors will be effective in an entirely different context (GBM) is what this trial is trying to determine.
In mouse models, the TMZ-sensitizing effect of veliparib was dependent on MGMT status. In other mouse models, some agents that have been able to suppress or downregulate MGMT are: levetiracetam/Keppra, fluoxetine/Prozac, and disulfiram, so patients with MGMT-unmethylated GBM could theoretically benefit from such treatments.
https://www.ncbi.nlm.nih.gov/pubmed/26615020
Are there any results available from veliparib trials in humans?
DeleteYes, the most recent result is here:
Deletehttps://www.ncbi.nlm.nih.gov/pubmed/27803064
This was a trial for advanced lung cancer. 2/3rds of the participants got carboplatin + paclitaxel + veliparib and 1/3 got carboplatin + paclitaxel plus placebo (158 patients in total).
The veliparib arm had a trend towards improved PFS and overall survival but the differences didn't reach formal statistical significance.
Of course this trial can't predict how well it will work for a completely different type of cancer added to a completely different chemo regimen.
I am new here and any reply will be appreciated. I need help.
ReplyDeleteThe more I read the more I'm overwhelmed.
ReplyDeleteIn this trial my husband has been given veliparib not placebo.
This is his histopatholgy post surgery removal left parietal tumour
ATRX: retained
IDH1 (r13211) immunonegative
EGFR; strongly and diffusely positive
P53: positive in approximately 30% of the tumour cells
Ki67 prolification index: approximately 20%
Glioblastoma IDH-wild type WIIO (2016) grade 4
I'm having difficulty working out what all the above means. I think IDH wild type unmethalated must be extremely aggressive?
He is in last week radiotherapy
I have had no help understanding what extra products to give as all the advise is to "continue the trial treatment."
I have had no help understanding what extra products to give as all the advise is to "continue the trial standard treatment "
This is what I have put together and would like some feedback if this is ok?
He is on ketogenic diet.
Flax oil with cottage cheese (x4 tablespoon daily)
Fish oil 1000mg (x2 daily)
Boswellia topical oil (rubbed on head + inhaled)
Vitamin c 1g (x2 daily)
Lyphodran Plus: Quercetin 500mg / Rutin 400mg / Bromelains 125mg / absorbing Acid 50mg (x3 daily)
I have just bought...
Borage seed oil 1000mg
Selenium 200mcg
I have these meds on order...
PSK
Melatonin
Not sure if anything counteracts each other or is harmful or what dosages to give.
Any any advice is welcome