Saturday, 26 March 2016

Noscapine

Anyone used the cough medication- Noscapine? I read on another group that it crosses the blood brain barrier, is synergetic with Temodar, BCNU and cisplatin. A long term GBM survivor used it in 2009 .,. If someone else used it on this group, can you pls share your experience and if you know if it has any contradictions with Avastin and/ or PD-1?

Thanks
Noha
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9 comments:

  1. Anonymous26 March 2016 at 16:35

    Seams promising where would you buy it from ?

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  2. Stephen W26 March 2016 at 17:11

    I believe it's hard to find in North America, but I know people who have purchased it as a cough medicine in Europe.

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  3. Anonymous27 March 2016 at 00:41

    Stephen given that it is a cough medicine would it be okay mixing with Disulfiram

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  4. Anonymous27 March 2016 at 01:47

    I can't find it any where, and I'm in the uk

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  5. Unknown27 March 2016 at 07:59

    I found this: https://www.buyldn.com/our-catalog/noscapine-caps.html

    I have not tried them. I was just looking where to get it and found that. I know it is available in Canada, Mexico and some parts of Europe

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  6. Unknown27 March 2016 at 08:00

    Stephen, do you know if it would contradict with Avastin or PD-1? Thanks so much

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  7. Stephen W27 March 2016 at 09:51

    See the list of brand names on this page for countries where it is marketed.

    http://www.drugs.com/international/noscapine.html

    Here is one example of a product available in Germany:

    https://www.europa-apotheek.com/capval-hustensaft-1672693.html

    I'm not sure if it would be okay to take with disulfiram. You would have to carefully read the label to make sure it contains no ethanol (ethyl alcohol or simply "alcohol").

    There is some evidence that noscapine has anti-angiogenic effects (in mouse glioma models), as well as sensitizing tumors to radiation:

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572218/

    See also this article, showing anti-tumor effect in mice, without inhibiting primary immune responses:

    http://www.ncbi.nlm.nih.gov/pubmed/10941904

    I've not seen any information that would suggest it shouldn't be used with Avastin or PD-1 antibodies.

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  8. Unknown27 March 2016 at 15:05

    Thanks stephen

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  9. Anonymous29 March 2016 at 14:30

    Thank German website requires a prescribtion will keep looking thank you Stephen

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