Friday, 19 May 2017

Curcumin

Hi all,

My apologies if there is an answer to this somewhere on the blog here.

My ND recommends BCM-95 Curcumin. But I see most people use Longvida. I'm trying to figure out which is better for crossing the BBB. I know there is a Curcumin folder but I'm having a hard time accessing anything online right now.

So, thoughts, experiences, etc. with BCM-95? She says it's the one most researched.

Also, is there need to worry about curcumin causing the tumor to adapt? I've gotten a few studies to open and it seems to impact the tumor in a number of ways. Could this pose a risk?

Thank you.

Maria

2 comments:

  1. I prefer Longvida for two reasons: many brands say that their product is 100-fold (or something to that effect) more bioavailable than unformulated curcumin. Most studies of that type don't distinguish between curcumin and conjugated metabolites of curcumin such as curcumin glucuronide. For example, after high dosing of one popular brand of bioavailable curcumin (Meriva), there was no free, unconjugated curcumin in any of the plasma samples of the sujects - it was all conjugated. There's little reason to assume that conjugated curcumin would have similar activity to free unconjugated curcumin, and most of the studies on the effects of curcumin in the lab are done with non-conjugated curcumin. Studies with Longvida have specifically looked at plasma levels of free curcumin.

    "We found that the effects of curcumin glucuronide are weaker than those of curcumin and that this difference is related to relative absorption rates of curcumin and curcumin glucuronide into HepG2 cells."
    https://www.ncbi.nlm.nih.gov/pubmed/24423511

    The above is one of the only studies I've seen comparing activity of curcumin versus conjugated curcumin.

    The second reason I prefer Longvida, is that it was specifically designed by UCLA scientists to treat Alzheimers, and therefore for superior blood-brain barrier penetration.

    By now there may be even better brands than Longvida out there, but having more literature or research behind it (BCM-95), doesn't necessarily mean it's a better product, it may have just been around longer. BCM-95 was "next generation" in 2007
    http://www.lifeextension.com/magazine/2007/10/report_curcumin/page-01

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