The most exciting immunotherapy trial recruiting in Canada (in my opinion) is DNX-2401 (adenovirus) + pembrolizumab for recurrent GBM, recruiting in Toronto.https://clinicaltrials.gov/ct2/show/NCT02798406The phase 3 (randomized, placebo-controlled) ICT-107 trial is recruiting in Ontario and Quebec, but it's for newly diagnosed GBM, and I would guess that leukapheresis to obtain dendritic cells would have to be done prior to radiation. It's also a long way to travel with a chance of getting placebo.https://www.clinicaltrials.gov/ct2/show/NCT02546102Finally there are 3 checkpoint inhibitor trials recruiting for *newly diagnosed* GBM. Two are recruiting in Vancouver, one is testing nivolumab versus TMZ for GBM with unmethylated MGMT.https://clinicaltrials.gov/ct2/show/NCT02617589The other is testing standard of care plus either nivolumab or placebo.https://clinicaltrials.gov/ct2/show/NCT02667587The third checkpoint inhibitor trial is recruiting in Quebec for newly diagnosed GBM, testing avelumab (a PD-L1 antibody).https://clinicaltrials.gov/ct2/show/NCT03047473These are the only immunotherapy trials currently recruiting in Canada that I'm aware of, and only one of them is for recurrent GBM.
Stephen, Thanks.Best RegardsJames Zhou
James -I investigated the very same question last year when my cousin was being tested for GBM. There was only one neuro-oncologist in Vancouver and so there just isn't the research capacity there that is available in Toronto. Margaret
mstix: I agree with you. Limited sources in VancouverJames Zhou