Hello all,
My sister is currently preparing for treatments after a successful surgery. She has recurrent IDH1mut, MGMT methylated astrocytoma, previously grade 3, we're still waiting for pathology report from the latest surgery. Preliminary treatment plan is to have radiation therapy (recurrence is outside of the original tumor location) and then continue with CCNU.
I found this one study (Paradigm-trial) that studies olaparib in combination with RT.
Do you think it would be worth a try? This could be possible for us financially since the RT last only about a month so cost of olaparib would be reasonable.
Br,
Juha
This trial (PARADIGM-2) is for newly diagnosed glioblastoma, so it doesn't seem as though your sister would be eligible (recruiting grade IV GBM, without previous radiation treatment).
ReplyDeleteThere is a similar trial recruiting for recurrent GBM, but also doesn't seem she would be eligible, as it excludes patients with prior chemotherapy for recurrent disease, and would require the tumor be a grade IV.
https://clinicaltrials.gov/ct2/show/NCT01390571
Olaparib is already approved in North America and Europe for ovarian cancer, so you could try to get an off-label prescription but may have to pay out-of-pocket.
Hello Stephen!
ReplyDeleteWe also think that she's not eligible for the trials in this case, so the idea was to try our doctor to prescribe it and pay it ourselves.
We're a bit cautios since we haven't found any published results yet.