Hi again. Does anyone know anything about Boldine? Can't seem to find much for it on the internets. Is this available anywhere as an ingredient for a cocktail? Read a report from Invest New Drugs (2009) 27:517–525 DOI 10.1007/s10637-008-9203-7
Boldine: a potential new antiproliferative drug against glioma cell lines
Daniéli Gerhardt & Ana Paula Horn &
Mariana Maier Gaelzer & Rudimar Luiz Frozza &
Andrés Delgado-Cañedo & Alessandra Luiza Pelegrini &
Amélia T. Henriques & Guido Lenz & Christianne Salbego
from 2008 which looks quite interesting.
This reminds me of a post recently asking about thymoquinone.
ReplyDeletehttps://btcocktails.blogspot.com/2018/04/thymoquinone-nigella-sativa-inhalation.html#comment-form
Many of my comments in response to that post apply here too.
Sci-hub link to a PDF of the study on boldine here:
http://sci-hub.tw/https://link.springer.com/article/10.1007/s10637-008-9203-7
Boldine is an alkaloid purified from the boldo tree. You could purchase it (perhaps with difficulty) from chemical supply companies but these preparations are intended for laboratory use, not human use, and as far as I can tell there has never been a clinical trial with boldine proper. Therefore there is likely no information on dosing or safety in humans. I would advise against this.
As mentioned, boldine is purified from the boldo tree. Herbal products made from boldo are commercially available, but
"No clinical studies were located with mono-preparations containing boldo. Therefore it is concluded that there are no data to support boldo as a well-established medicinal product with recognised efficacy and acceptable safety."
http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_HMPC_assessment_report/2017/01/WC500219578.pdf
Apart from these considerations, in vitro studies are the weakest form of evidence and personally I wouldn't pay the slightest bit of attention to the study showing efficacy on cell lines at 80 - 500 micromolar. I would bet a large sum of money on the odds that you could not achieve anywhere near this concentration of boldine in blood plasma after oral ingestion, and especially not with an herbal preparation containing on the order of 0.1% alkaloids.
["Boldo leaf (boldi folium) is defined in the European Pharmacopoeia as the whole or fragmented dried leaf of Peumus boldus Molina. It contains not less than 0.1% of total alkaloids, expressed as boldine"}
If in vitro efficacy at nanomolar concentrations (1000 fold less than the concentrations used in the glioma study) could be demonstrated, I would pay slightly more attention.
I'd advise against spending much more time on this compound. There are dozens of substances with both superior evidence (dosing, safety, efficacy against brain tumors) as well as being more available commercially.
Thanks; definitely confirmed my suspicions as to why there aren't 33 people on Amazon selling it !!
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