The median PFS of 13.5 months is measured from diagnosis. Other trials of this type measure outcomes from treatment/randomization, which in this trial was about 3 months after diagnosis. 13.5 - 3 = 10.5 months from the start of treatment.
This data is quite preliminary because so many patients have not even been followed up for a year (see all the black ticks on the survival curves before 12 months).
Still, the vaccine was active and produced survivin-specific CD8+ T-cells. I hope the PFS and survival outcomes continue to look as promising with longer follow-up.
Every black tick represents a patient at the point of last follow up. As you can see, there are many patients with follow up less than one year still (who joined the trial more recently).
Thanks Mike. A couple things to note:
ReplyDeleteThe median PFS of 13.5 months is measured from diagnosis. Other trials of this type measure outcomes from treatment/randomization, which in this trial was about 3 months after diagnosis. 13.5 - 3 = 10.5 months from the start of treatment.
This data is quite preliminary because so many patients have not even been followed up for a year (see all the black ticks on the survival curves before 12 months).
Still, the vaccine was active and produced survivin-specific CD8+ T-cells. I hope the PFS and survival outcomes continue to look as promising with longer follow-up.
What does the black ticks mean?
ReplyDeleteEvery black tick represents a patient at the point of last follow up. As you can see, there are many patients with follow up less than one year still (who joined the trial more recently).
Delete