Wednesday, 6 June 2018

metabolic therapies

Hello all,
I'm wondering if anyone has tried the Care Oncology Clinic protocol? They are now in the U.S. and I'm considering it as an additional therapy for my husband. I'm interested in hearing about potential side effects of the drugs, what neuro-oncologists had to say about it, etc. Also, he's currently on a hydroxicytrate/ALA combo and I'm wondering which metabolic treatment would be best/has better data. He's also doing a combination of TMZ/CCNU.

Another question-- his most recent MRI shows radiation necrosis. Is there data that shows any natural treatments that could help?

Thank you all!

7 comments:

  1. For radiation necrosis, you could look at hyperbaric oxygen treatment.

    http://n.neurology.org/content/84/14_Supplement/P4.218

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    1. This is interesting, thanks for sharing. I asked his radiation oncologist if hyperbaric oxygen would help but he said data shows it doesn't... I'll have to look into it some more.

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  2. As for Care Oncology, I've heard they've had good results in GBM, but I haven't seen that the data has been published yet.

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  3. I presume you have already seen the below Care Oncology paper, which was also posted here on the blog back in March:

    https://presentations.yesware.com/f282692987bb2ea12dedb230dde95f633168f5ce/4c153fd23d93adfa8ccad258cbe53b1a/e5c138ccb8ec563ba4f54a01c3a774a8

    As for the four medications (Metformin, Atorvastatin, Doxycycline and Mebendazole), I've been taking these for the past three months (in addition to Celebrex) without any problems or side effects.I did have some minor gastric issues / bloating / very slight nausea etc. over the first few weeks or so, probably due to scaling up Metformin (which is notorious for these side effects) to the 1000mg bid level. However, my experience has been that the side effects completely subside after some time, and I have literally zero now.

    I should note I'm not taking the full dosage of Atorvastatin, though (just 20mg daily), as I was a bit concerned about in-vitro studies showing it might potentially have a negative reaction with IDH1 mutantion, which I have.

    I'm also thinking about adding the Hydroxicytrate/ALA combo, so would also be interested if this can be combined effectively.

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    1. Thanks John. I have seen their white paper. It does look promising and is definitely something I'm considering, I was just hoping to see more data from the actual trial. Nice to know that you don't have side effects. Did you go through the Care Oncology Clinic or did you source the prescriptions for these medications through your own doctor? Do you mind sharing the studies about the potential reaction of Atorvastatin with IDH1-mutant tumors? My husband's tumor is also IDH1-mutant. I'm also concerned if this treatment protocol would prohibit him from participating in clinical trials in the future... I guess it depends on the trial.

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    2. The atorvastatin, IDH1 study was discussed briefly in the comments here:

      http://btcocktails.blogspot.com/2018/02/idh1-r132h-mutation-enhances-cell.html#comment-form

      In the study, high concentrations of atorvastatin caused a compensatory increase in SREBP2 expression. SREBP2 is a transcription factor that helps activate cholesterol synthesis. This led to increased IDH1 expression and production of 2-hydroxyglutarate in a cell line with mutant IDH1.

      As I mentioned in the comment on the other post, the atorvastatin concentrations used in that study are far higher than ones you would get in the real world with normal dosing, so I'm not sure that is even a concern in reality.

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  4. My husband is on the Care Oncology Care protocol. He staryes two weeks before he started treatment this week. I asked a ND about Hxdroxychloroquine and she was opposed to it. Did any of you also added supplents with your cocktail. I read about HBOT too. Going to set it up for my husband.

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