I've been trying understand the applicability of Sildenafil specifically for low grade tumors which inherently have minimally if any disruption of the blood brain barrier.
I have not been able to find much more than a few decent studies. 2 of them are one AstrocytomaOptions:
and one other good one I found was:
Here on btcoctails its referenced in the range of 20-40mg total dose per day, but this and a few other studies showed 50mg per kg dosing in rat models which is maybe 500x higher. But I haven't found plasma concentration info to actually map it to human dosing. The closest I found was pharmocokinetic comparisons listing equivalent half lives between rat and human and coming up with the half life for humans being about 4x longer than in rats. That was useful because it indicates that dose timing should be stretched out to match Tmax of sildenafil with Tmax of chemo. But actual dosage that would be sensible and safe I haven't been able to figure out.
So does anyone have input on tying it with an actual chemo rounds or recommendations on a sensible dosage?