My husband is about to begin ABT-414 for his first recurrence following RT and 4 mos. of TMZ 5/23. He is methylated, IDH Wild Type, high amplified EGFR and P53 mutated.
Prior to Recurrence he was on:
Keppra 1500 mg 2x/d
Metformin 1000 mg 2x/d
Aspirin 81 mg daily
Boswellia 333 mg 3x's/d
Berberine 250 mg 2x's/d
R-Lipoic Acid 240 mg 2x's/d
TurkeyTail Super Strength Coriolus
Melatonin 20 mg
Hydroxycitrate 500 mg 3x's/d
Shark Liver Oil
Zinc 50 mg 2x's/d (Holding due to diarrhea)
TMZ 5/23
Ondansetron
CBD tincture (Stopped because of concern about disulfiram reaction bc manufacturing process utilizes alcohol. Could not tolerate even low dose THC.)
Since Recurrence:
Metronomic TMZ 100 mg daily
Keppra
Metformin
Chloroquine 250 mg daily
Celebrex 300 mg 2x's/d
Disulfiram 250 mg twice daily
Captopril 50 mg 2x's/d
Minocycline 50 mg 2x's/d (Holding due to diarrhea)
Boswellia
R-Lipoic Acid
Hydroxycitrate
DCA 500 mg
Melatonin 20 mg
Longvida Curcumin 1000 mg 2x's/d (Holding due potential CYP450 inhibition)
Probiotics
(Could not tolerate low dose sertraline due to insomnia/agitation)
His CBC and CMP are completely normal since discontinuing TMZ 5/23.
-What would be a safe and strategic augmentation cocktail to combine with ABT-414?
-Any thoughts on managing the diarrhea and other drugs or supplements to hold? Based on his symptoms and an abdominal X-ray, his PCP feels he has slowed gut motility possibly secondary to Ondansetron and his other meds. She has him on a current regimen of Reglan and Miralax.
Gratitude for all guidance offered!
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