advices on cocktails and corticoids

My father in France - 71 years old - has been diagnosed with a GBM grade IV in September 2018. Before that he has always been in good shape and was very sportive.
He has 3 tumors from 10mm to 40mm and seems to be inoperable. He already had 3 sets of TMZ and he is taking already some supplements I recommended based on my researches on Internet. 
Here is his complete current treatment started 1 month after first diagnosis (time to perform biopsy) :

Temodal	3 cycles of 5 days done
Corticoids - Solupred	50 to 60 mg / day
Cannabis suppositories	1g / day (80% THC)
Chinese herbs and mushrooms (including Artemisia Annua)	every day
Vitamin C	5g / day
Nutraexpert Lipo HCA dietary suplements containing:
HCA	1500 mg / day
Alpha Lipoic Acid	1600 mg / day
Capsicum	112 mg/ day
Quercetin	45 mg/ day
Ginger	46 mg/ day
Whey	47 mg/ day
Green tea	30 mg/ day
Nicotinamid	20 mg/ day
Vitamin D3	25 µg/ 1000 UI
Ketogenic diet
Curcuma (Longvida) : added last week	1g / day

Biopsy revealed :

• IDH1 : negative
• FGFR3 : negative
• P53 protein : 15 - 20%
• no information on MGMT

MRI performed early december has show a slight size increase in the 2 biggest tumors, the oncologist says it is not alarming as the treament started one month after first diagnosis.
Currently my father resists well and tries to keep daily walking activity. Next MRI will be next month. 

I just recently discovered the cocktail approach and your blog and I have some questions.

1. It seems many patients are taking Melatonin 20 mg/ day (forbidden in France at this dosage by the way) and that it could be of good help : sustains the immune system, anti-oxidant, anti inflammatory, leads to cancer cells suicide ... Should I add Melatonin to the treatment ? It seems also that Malatonin is non compliant with corticoids as it inhibits corticoids effects : what do you think ?

2. More globally I fear corticoids may have a negative impact on the different supplements. Is there a mean to sustitute it by anything else ? Is Celebrex an option ? If so at which dosage ? (the inflammation is still important, but decreasing).

3. Would you have any recommandation in other supplements or drugs ? PSK mushroom, Valpoic Acid, Metformin? 

Thank you very much for your precious help.

Celebrex post-Avastin?

Hi all,

My brother received his first Avastin treatments over the past few months and suffered a brain bleed. After he was stabilized, his NO said we needed to take a break from Avastin and re-evaluate after 1 month. James was also on Xarelto during this Avastin treatment due to a blood clot that formed in his leg. He is no longer taking Xarelto.

James desperately wants to get off of steroids and is beginning to dose down. He's previously done OK dosing down slowly, but I wanted to ask about introducing Celebrex.

I'm concerned that maybe it could be a bad idea due to the brain bleed? The bleed has not fully "absorbed" so it is still present, though it is under control.

Any previous experiences or references would be greatly appreciated.

Thanks!

Baseline corticosteroids reduce activity of PD-L1 blockade

https://www.ncbi.nlm.nih.gov/pubmed/30125216 
Impact of Baseline Steroids on Efficacy of Programmed Cell Death-1 and Programmed Death-Ligand 1 Blockade in Patients With Non-Small-Cell Lung Cancer

http://sci-hub.tw/https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30666-1/fulltext  (summary of study published in the Lancet)

"Baseline corticosteroid use was associated with decreased overall response, and shorter median progression-free survival and overall survival in patients who received the equivalent to 10 mg prednisone or more per day at the start of the PD-L1 blockade."

10 mg of prednisone is equivalent to only 1.6 mg of dexamethasone.

http://clincalc.com/corticosteroids/

Steroid taper

Hi all,

My dad is on the last leg of his steroid taper and is really struggling. Extreme fatigue and total loss of appetite as well being highly emotional. I think these are all common withdrawal symptoms but was wondering if anyone knows of anything that might help?

Hydrocortisone VS Prednisone

My husband, diagnosed May 2015 with left frontal lobe GBM, had been using dexamethasone but the side-effect were becoming too severe even though he was down to 2mg per day. His arms easily bruised, bleeding from thinning skin. Does anyone here have any experience with Prednisone or hydrocortisone? Since Dec. 1, my husband started taking prednisone but he seems to get quite irritable even on 7.5mg. A friend, who happens to be a neuro-onc visiting from Scotland, recommended switching over to hydrocortisone.  Our UCLA neuro-onc recommends that we see an endocrinologist, but that's harder to find than you would think. Any conflicts with other off-labels meds or supplements? Thoughts?