I am wanting to know how those of you using this drug were able to convince your NO to prescribe, what you are using in combination and your rationale. Also any effects you have seen or experienced with using thalidomide.
Aunt Jo
Showing posts with label thalidomide. Show all posts
Showing posts with label thalidomide. Show all posts
Thursday, 24 September 2015
Wednesday, 23 September 2015
Help on Accutane/PCV interaction
Hi All,
This is my first post so far, thanks to all for the knowledge shared especially to Stephen for the time he spends on this.
My wife was diagnosed 2 months ago with a GBM (mutated IDH1 / no MGNT) , It evolved from 2 full resection (201203-AAG3 / 201504-AAG3). Due to the internal capsule in compromised, there is a high risk of hemiplegia, so NO decided to apply PCV protocol in order to produce some regression that may help the work of the NS in a future surgery, decreasing the chance of collateral damage. Her tumour growth was fast in the last 3 months, but after the first PCV it has been stabilized. At that time we found Ben Williams story, Astrocytoma Options web, so we decided to follow cocktail aproach to create sinergy. She is now in the 2nd PCV cycle and we added Tamoxifen, Verapamil, Celebrex, Metformin and a bunch of suplements like Curcumine, Boswellia, Resveratrol, Fish Oil and a couple more. So now we want to add Accutane but we want to be aware of any possible interactions with PCV and avoid them.
PCV Protocol:
Any advice on when she should take Accutane?
Thanks in advance.
Francisco.
This is my first post so far, thanks to all for the knowledge shared especially to Stephen for the time he spends on this.
My wife was diagnosed 2 months ago with a GBM (mutated IDH1 / no MGNT) , It evolved from 2 full resection (201203-AAG3 / 201504-AAG3). Due to the internal capsule in compromised, there is a high risk of hemiplegia, so NO decided to apply PCV protocol in order to produce some regression that may help the work of the NS in a future surgery, decreasing the chance of collateral damage. Her tumour growth was fast in the last 3 months, but after the first PCV it has been stabilized. At that time we found Ben Williams story, Astrocytoma Options web, so we decided to follow cocktail aproach to create sinergy. She is now in the 2nd PCV cycle and we added Tamoxifen, Verapamil, Celebrex, Metformin and a bunch of suplements like Curcumine, Boswellia, Resveratrol, Fish Oil and a couple more. So now we want to add Accutane but we want to be aware of any possible interactions with PCV and avoid them.
PCV Protocol:
- Day 1 - Lomustine.
- Day 8 till 21 Procarbazine.
- Day 8 and 29 Vincristine.
- 2 weeks off.
Any advice on when she should take Accutane?
Thanks in advance.
Francisco.
Monday, 14 September 2015
13-cis retinoic acid (Accutane) and thalidomide combination in GBM mouse model
Inhibition of 13-cis retinoic acid-induced gene expression of reactive-resistance genes by thalidomide in glioblastoma tumours in vivo
In this study, nude mice bearing subcutaneous U251 GBM xenografts were treated orally with either 13-cis retinoic acid (Accutane), or thalidomide, or both. While neither of the drugs alone influenced tumor growth rates, the combination of both drugs significantly slowed tumor growth up to day 18.
I'm not adding this to the library as it is available as a free download from Oncotarget (click on link above).
In this study, nude mice bearing subcutaneous U251 GBM xenografts were treated orally with either 13-cis retinoic acid (Accutane), or thalidomide, or both. While neither of the drugs alone influenced tumor growth rates, the combination of both drugs significantly slowed tumor growth up to day 18.
I'm not adding this to the library as it is available as a free download from Oncotarget (click on link above).
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